Department of Molecular Medicine
 

Chung-Seog Song Chung-Seog  SongPh.D.

Assistant Professor/Research


Profile and Contact Information | Research


RESEARCH

 

Research Program

My expertise is in biochemistry, immunology, and molecular biology. I am leading the effort in Dr. Bandana Chatterjee’s laboratory to identify methylation-dependent differential coregulator interaction with the androgen receptor and the role of the differentially interacting putative coregulator in androgen receptor activity in cultured cells and in vivo in xenograft tumors.

 

Selected Publications

  1. Seo YK, Mirkheshti N, Song CS, Kim S, Dodds S, Ahn SC, Christy B, Mendez-Meza R, Ittmann MM, Abboud-Werner S, Chatterjee B. SULT2B1b sulfotransferase: induction by vitamin D receptor and reduced expression in prostate cancer. Mol Endocrinol. 2013 Jun;27(6):925-39.
  2. Kim KY, Cho HJ, Yu SN, Kim SH, Yu HS, Park YM, Mirkheshti N, Kim SY, Song CS, Chatterjee B, Ahn SC. Interplay of reactive oxygen species, intracellular Ca2+ and mitochondrial homeostasis in the apoptosis of prostate cancer cells by deoxypodophyllotoxin. J Cell Biochem. 2013 May;114(5):1124-34. doi: 10.1002/jcb.24455.
  3. Kim KY, Cho HJ, Yu SN, Kim SH, Yu HS, Park YM, Mirkheshti N, Kim SY, Song CS, Chatterjee B, Ahn SC: (2013) Interplay of reactive oxygen species, intracellular Ca(2+) and mitochondrial homeostasis in the apoptosis of prostate cancer cells by deoxypodophyllotoxin. J Cell Biochem. 114(5): 1124-34.
  4. Seo YK, Mirkheshti N, Song CS, Kim S, Dodds S, Ahn SC, Christy B, Mendez-Meza R, Ittmann MM, Abboud-Werner S, Chatterjee B: (2013) SULT2B1b sulfotransferase: induction by vitamin D receptor and reduced expression in prostate cancer. Mol Endocrinol. 27(6): 925-39.
  5. Kim KY, Yu SN, Lee SY, Chun SS, Choi YL, Park YM, Song CS, Chatterjee B, and Ahn SC: (2011) Salinomycin-induced apoptosis of human prostate cancer cells due to accumulated reactive oxygen species and mitochondrial membrane depolarization. Biochem Biophys Res Commun. 413(1): 80-6.
  6. Ko S, Ahn J, Song CS, Kim S, Knapczyk-Stwora K, and Chatterjee B: (2011) Lysine methylation and functional modulation of androgen receptor by Set9 methyltransferase. Mol Endocrinol. 25(3): 433-44.
  7. Shi L, Ko S, Kim S, Echchgadda I, Oh TS, Song CS, Chatterjee B: (2008) Loss of androgen receptor in aging and oxidative stress through the Myb protooncoprotein-regulated reciprocal chromatin dynamics of p53 and poly(ADP-ribose) polymerase PARP-1. J Biol Chem 283(52): 36474-85.
  8. KoS, Shi L, Kim SY, Song CS, Chatterjee B: (2008) Interplay of nuclear factor-kappaB and B-myb in the negative regulation of androgen receptor expression by tumor necrosis factor alpha. Mol Endocrinol. 22(2): 273-86.
  9. Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ, and Chatterjee B: (2007) The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase. Mol Endocrinol. 21(9): 2099-111.
  10. Seo YK, Chung YT, Kim S, Echchgadda I, Song CS, and Chatterjee B: (2007) Xenobiotic- and vitamin D-responsive induction of the steroid/bile acid-sulfotransferase Sult2A1 in young and old mice: the role of a gene enhancer in the liver chromatin. Gene. 386(1-2): 218-23.
  11. Song CS, Echchgadda I, Seo YK, Oh T, Kim S, Kim SA, Cho S, Shi L, and Chatterjee B>: (2006) An essential role of the CAAT/enhancer binding protein-alpha in the vitamin D-induced expression of the human steroid/bile acid-sulfotransferase (SULT2A1). Mol Endocrinol. 20(4): 795-808.
  12. Chatterjee B, Echchgadda I, and Song CS: (2005) Vitamin D receptor regulation of the steroid/bile acid sulfotransferase SULT2A1. Methods Enzymol., “Phase II: Conjugation Enzymes, Glutathione Transferases and Transport Systems." 400: 165-91.
  13. Echchgadda I, Song CS, Roy AK, and Chatterjee B: (2004) Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor. Mol Pharmacol. 65(3): 720-9.
  14. Zhang L, Charron M, Wright WW, Chatterjee B, Song CS, Roy AK, and Brown TR: (2004) Nuclear factor-kappaB activates transcription of the androgen receptor gene in Sertoli cells isolated from testes of adult rats. Endocrinology. 145(2): 781-9.
  15. Rivera OJ, Song CS, Centonze VE, Lechleiter JD, Chatterjee B,and Roy AK: (2003) Role of the promyelocytic leukemia body in the dynamic interaction between the androgen receptor and steroid receptor coactivator-1 in living cells. Mol Endocrinol. 17(1): 128-40. (cover article)
  16. Song CS, Echchgadda I, Baek BS, Ahn SC, Oh T, Roy AK, and Chatterjee B: (2001) Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor. J Biol Chem. 276(45): 42549-56.
  17. Tyagi RK, Lavrovsky Y, Ahn SC, Song CS, Chatterjee B, and Roy AK: (2000) Dynamics of intracellular movement and nucleocytoplasmic recycling of the ligand-activated androgen receptor in living cells. Mol Endocrinol. 14(8): 1162-74. (cover article)
  18. Chen S, Song CS, Lavrovsky Y, Bi B, Vellanoweth R, Chatterjee B, and Roy AK: (1998) Catalytic cleavage of the androgen receptor messenger RNA and functional inhibition of androgen receptor activity by a hammerhead ribozyme. Mol Endocrinol. 12(10): 1558-66. (cover article)
  19. Song CS, Jung MH, Kim SC, Hassan T, Roy AK, and Chatterjee B: (1998) Tissue-specific and androgen-repressible regulation of the rat dehydroepiandrosterone sulfotransferase gene promoter. J Biol Chem. 273(34): 21856-66.