Department of Molecular Medicine
 

[ default picture ] Sribalasubashini  MuralimanoharanPh.D.

Instructor/Research


Profile and Contact Information | Research


RESEARCH

 

Research Program

I am a Biochemist by training and have expertise in the field of plancentology, obesity, diabetes and cancer. During my first post-doctoral training, I studied the chemopreventive role of Nexurutine in prostate cancer. Later I spent 5 years of my postdoctoral research on understanding the role of miRNA in placental functions, especially during pregnancy related complications including preeeclampsia, obesity and gestational diabetes. I have also expanded my work in understanding the epigenetic and chromatin modification during trophoblast differentiation which is critical for placental function. Currently I will be working on understanding the molecular basis of Mediator subunit 12 (MED-12) mutations in uterine leiomyomas.

 

Selected Publications

  1. Muralimanoharan S, Li C, Nakayasu ES, Casey CP, Metz TO, Nathanielsz PW, Maloyan A. Sexual dimorphism in the fetal cardiac response to maternal nutrient restriction. J Mol Cell Cardiol. 2017 Jul;108:181-193.

  2. Zhang M, Muralimanoharan S, Wortman AC, Mendelson CR. Primate-specific miR-515 family members inhibit key genes in human trophoblast differentiation and are upregulated in preeclampsia. Proc Natl Acad Sci U S A. 2016 Oct 24.

  3. Muralimanoharan S, Maloyan A, Myatt L. Mitochondrial function and glucose metabolism in the placenta with gestational diabetes mellitus: role of miR-143. Clin Sci (Lond). 2016 Jun 1;130(11):931-41.

  4. Muralimanoharan S, Gao X, Weintraub S, Myatt L, Maloyan A. Sexual dimorphism in activation of placental autophagy in obese women with evidence for fetal programming from a placenta-specific mouse model. Autophagy. 2016 May 3;12(5):752-69.

  5. Muralimanoharan S, Guo C, Myatt L, Maloyan A. Sexual dimorphism in miR-210 expression and mitochondrial dysfunction in the placenta with maternal obesity. Int J Obes (Lond). 2015 Aug;39(8):1274-81.

  6. Myatt L, Muralimanoharan S, Maloyan A. Effect of preeclampsia on placental function: influence of sexual dimorphism, microRNA's and mitochondria. Adv Exp Med Biol. 2014;814:133-46. doi: 10.1007/978-1-4939-1031-1_12. Review.

  7. Muralimanoharan S, Maloyan A, Myatt L. Evidence of sexual dimorphism in the placental function with severe preeclampsia. Placenta. 2013 Dec;34(12):1183-9.

  8. Maloyan A, Muralimanoharan S, Huffman S, Cox LA, Nathanielsz PW, Myatt L, Nijland Identification and comparative analyses of myocardial miRNAs involved in the fetal response to maternal obesity. Physiol Genomics. 2013 Oct 1;45(19).

  9. Muralimanoharan S, Maloyan A, Mele J, Guo C, Myatt LG, Myatt L. MIR-210 modulates mitochondrial respiration in placenta with preeclampsia. Placenta. 2012 Oct;33(10):816-23.

  10. Muralimanoharan SB, Kunnumakkara AB, Shylesh B, Kulkarni KH, Haiyan X, Ming H, Aggarwal BB, Rita G, Kumar AP. Butanol fraction containing berberine or related compound from nexrutine inhibits NFkappaB signaling and induces apoptosis in prostate cancer cells. Prostate. 2009 Apr 1;69(5):494-504.

  11. Cara Horny, Muralimanoharan Sribalsubashini, Krishna Komanduri, Manonmani Ganapathy, I-Tien yeh, Rita Ghosh and Addanki P Kumar. 2-methoxyestradiol prevents LNCaP tumor development in nude mice: Potential role of G2/M regulatory proteins. Journal of Cell Death. 2009: (2)1-8.

  12. Sribalasubashini.M, Karthigayan. S, SomasundaramS.T, Balasubramanina. T, Viswanathan. P, Venugopal P Menon. In vivo and In vitro Characterization of the Biochemical and Pathological Changes Induced By Lionfish (Pterios Volitans) venom in Mice. Tox.Mech.Met. 2006 16 (1): 1-7.

  13. Sribalasubashini. M, Karthigayan. S, SomasundaramS.T, Balasubramanina. T, Viswanathan. P, Raveendran. P, Venugopal P Menon.Fish venom (Pterios volitans) peptide reduces tumour burden and ameliorates oxidative stress in Ehrlich’s ascites carcinoma xenografted mice. Bioorg Med Chem Lett. 2006 16: 6219-6225.

  14. Sribalasubashini.M, Karthigayan. S, SomasundaramS.T, Balasubramanina. T, Venugopal P Menon. FV peptide induces apoptosis in HEp 2 and HeLa cells: an insight into the mechanism of induction. J Carcinogenesis. 2006 5 (27):1-9.

  15. Sribalasubashini.M, R.Rukkumani and V.P.Menon. Protective effects of ferulic acid on Hyperlipidemic diabetic rats. Acta. Diabetol (2003) 40: 118-22.

  16. M.Sribalasubashini, R.Rukkumani and V.P.Menon. Ferulic acid alleviates lipid peroxidation in diabetic rats, Phytother.Res . (2004). 18: 310-314.

  17. Thirunavukarasu Mahesh, Muralimanoharan Sribalasubashini and Venugopal Padmanabhan menon. Photo – Irradiated curcumin supplementation in streptozotocin-induced Diabetic Rats: Effect on lipid peroxidation. Therepie (2004) 59: 639-644.

  18. R.Rukkumani, M.Sribalasubashini and V.P.Menon Protective effects of curcumin and photoirradiated curcumin on circulatory lipids andlipid peroxidation products in alcohol and polyunsaturated fatty acid induced toxicity. Phytother.Res. (2003) 17.925-29.

  19. R.Rukkumani, M.Sribalasubashini and V.P.Menon. Comparative effects of curcumin and photo-irradiated curcumin on alcohol and polyunsaturated fatty acid induced hyperlipidemia. Pharmacol.Res. (2002) 46: 49-4

  20. T.Mahesh, M.Sribalasubashini and Venugopal P. Menon. Effect of photo- irradiated curcumin treatment against oxidative stress in streptozotocin induced diabetic rats. J Med Food (2005) 8(2): 251-255.

  21. Karthigayan. S, Sribalasubashini. M, Sengottuvelan. M, Balasubramanina. T, Somasundaram. S.T, Anticancer Principles from salivary gland extract of Octopus ageina. IJCR. 2006 2 (3): 242-252.

  22. Karthigayan. S, Sribalasubashini. M, Sengottuvelan. M, Balasubramanina. T, Somasundaram. S.T. PGEfrom O.segina induces apoptosis in Ehrlich’s ascites carcinoma of mice. Toxicol Mech Meth. 2007, 17 (8): 451-458.