Department of Molecular Medicine
 

[ default picture ] Kohzoh  MitsuyaPh.D.

Assistant Professor/Research


Profile and Contact Information | Research


RESEARCH

 

Selected Publications

  1. Kohzoh Mitsuya, Ashley N. Parker, Lu Liu, Jianhua Ruan, Margreet C.M. Vissers and Leslie Myatt (2017) Alterations in the placental methylome with maternal obesity and evidence for metabolic regulation. PLoS ONE 12 (10): e0186115.

  2. Kohzoh Mitsuya, Natasha Singh, Suren R. Sooranna, Mark R. Johnson and Leslie Myatt (2014) Epigenetics of Human Myometrium: DNA Methylation of Genes Encoding Contraction-Associated Proteins in Term and Preterm Labor. Biology of Reproduction 90 (5): 98-105.

  3. Toshiaki Watanabe, Shin-ichi Tomizawa, Kohzoh Mitsuya, Yasushi Totoki, Yasuhiro Yamamoto, Satomi Kuramochi-Miyagawa, Naoko Iida, Yuko Hoki, Patrick J. Murphy, Atsushi Toyoda, Kengo Gotoh, Hitoshi Hiura, Takahiro Arima, Asao Fujiyama, Takashi Sado, Tatsuhiro Shibata, Toru Nakano, Haifan Lin, Kenji Ichiyanagi, Paul D. Soloway and Hiroyuki Sasaki (2011) Role for piRNAs and Noncoding RNA in de Novo DNA Methylation of the Imprinted Mouse Rasgrf1 Locus. Science 332 (6031): 848-852.

  4. Mark J. Nijland*, Kohzoh Mitsuya* (*co-first authors with equal contribution), Cun Li, Stephen Ford, Thomas J. McDonald, Peter W. Nathanielsz and Laura A. Cox (2010) Epigenetic modification of fetal baboon hepatic phosphoenolpyruvate carboxykinase following exposure to moderately reduced nutrient availability. Journal of Physiology 588 (8): 1349-1359.

  5. Jafar Sharif*, Masahiro Muto*, Shin-ichiro Takebayashi* (*co-first authors with equal contribution), Isao Suetake, Akihiro Iwamatsu, Takaho A. Endo, Jun Shinga, Yoko Mizutani-Koseki, Tetsuro Toyoda, Kunihiro Okamura, Shoji Tajima, Kohzoh Mitsuya†, Masaki Okano† and Haruhiko Koseki† (†co-senior authors with equal contribution) (2007) The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA. Nature 450 (7171): 908-912.

  6. Jafar Sharif*, Michiyo Nakamura, Takuya Ito, Yoshitaka Kimura, Teruyuki Nagamune, Kohzoh Mitsuya* (*corresponding authors), and Kunihiro Okamura (2007) Food restriction in pregnant mice can induce changes in histone modifications and suppress gene expression in fetus. Nucleic Acids Symposium Series 51: 125-126.

  7. Masayuki Haruta, Makiko Meguro, Yu-ki Sakamoto, Hidetoshi Hoshiya, Akiko Kashiwagi, Yasuhiko Kaneko, Kohzoh Mitsuya and Mitsuo Oshimura (2005) Narrowed abrogation of the Angelman syndrome critical interval on human chromosome 15 does not interfere with epigenotype maintenance in somatic cells. Journal of Human Genetics 50 (3): 124-132.

  8. Annabelle Lewis*, Kohzoh Mitsuya* (*co-first authors with equal contribution), David Umlauf, Paul Smith, Wendy Dean, Joern Walter, Michael Higgins, Robert Feil and Wolf Reik (2004) Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation. Nature Genetics 36 (12): 1291-1295.

  9. Annabelle Lewis, Kohzoh Mitsuya, Miguel Constancia and Wolf Reik (2004) Tandem repeat hypothesis in imprinting: deletion of a conserved direct repeat element upstream of H19 has no effect on imprinting in the Igf2-H19 region. Molecular and Cellular Biology 24 (13): 5650-5656.

  10. Takahiro Yamada, Kohzoh Mitsuya, Tomohiko Kayashima, Kentaro Yamasaki, Tohru Ohta, Koh-ichiro Yoshiura, Naomichi Matsumoto, Hideto Yamada, Hisanori Minakami, Mitsuo Oshimura, Norio Niikawa and Tatsuya Kishino (2004) Imprinting analysis of 10 genes and/or transcripts in a 1.5-Mb MEST-flanking region at human chromosome 7q32. Genomics 83 (3): 402-412.

  11. Wolf Reik, Adelle Murrell, Annabelle Lewis, Kohzoh Mitsuya, David Umlauf, Wendy Dean, Michael Higgins and Robert Feil (2004) Chromosome loops, insulators, and histone methylation: new insights into regulation of imprinting in clusters. Cold Spring Harbor Symposia on Quantitative Biology Symposium 69: 29-38.

  12. Flavia Cerrato, Wendy Dean, Karen Davies, Kazuhiro Kagotani, Kohzoh Mitsuya, Katsuzumi Okumura, Andrea Riccio and Wolf Reik (2003) Molecular genetic studies of human chromosome 7 in Russell-Silver syndrome. Human Molecular Genetics 12 (23): 3123-3132.

  13. Wolf Reik, Fatima Santos, Kohzoh Mitsuya, Hugh Morgan and Wendy Dean (2003) Epigenetic asymmetry in the mammalian zygote and early embryo: relationship to lineage commitment? Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 358 (1436): 1403-1409.

  14. Kazuhiko Nakabayashi, Louise Bentley, Megan P. Hitchins, Kohzoh Mitsuya, Makiko Meguro, Sachi Minagawa, John S. Bamforth, Philip Stanier, Michael Preece, Rosanna Weksberg, Mitsuo Oshimura, Gudrun E. Moore and Stephen W. Scherer (2002) Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32. Human Molecular Genetics 11 (15): 1743-1756.

  15. Kazuhiko Nakabayashi, Bridget A. Fernandez, Ikuko Teshima, Cheryl Shuman, Virginia K. Proud, Cynthia J. Curry, David Chitayat, Theresa Grebe, Jeffrey Ming, Mitsuo Oshimura, Makiko Meguro, Kohzoh Mitsuya, Paromita Deb-Rinker, Jo-Anne Herbrick, Rosanna Weksberg and Stephen W. Scherer (2002) Molecular genetic studies of human chromosome 7 in Russell-Silver syndrome. Genomics 79 (2): 186-196.

  16. Takashi Sakatani, Michelle Wei, Motonobu Katoh, Chiga Okita, Daisuke Wada, Kohzoh Mitsuya, Makiko Meguro, Masahide Ikeguchi, Hisao Ito, Benjamin Tycko and Mitsuo Oshimura M (2001) Epigenetic heterogeneity at imprinted loci in normal populations. Biochemical and Biophysical Research Communications 283 (5): 1124-1130.

  17. Makiko Meguro*, Akiko Kashiwagi* (*co-first authors with equal contribution), Kohzoh Mitsuya, Mitsuyoshi Nakao, Ikuko Kondo, Shinji Saitoh and Mitsuo Oshimura (2001) A novel maternally expressed gene, ATP10C, encodes a putative aminophospholipid translocase associated with Angelman syndrome. Nature Genetics 28 (1): 19-20.

  18. Jun Inoue, Kohzoh Mitsuya, Shinji Maegawa, Hiroyuki Kugoh, Mitsutaka Kadota, Daiji Okamura, Tokuyuki Shinohara, Shigeki Nishihara, Shoko Takehara, Kaori Yamauchi, Thomas C. Schulz and Mitsuo Oshimura (2001) Construction of 700 human/mouse A9 monochromosomal hybrids and analysis of imprinted genes on human chromosome 6. Journal of Human Genetics 46 (3): 137-145.

  19. Makiko Meguro, Kohzoh Mitsuya, Nobuo Nomura, Masakazu Kohda, Akiko Kashiwagi, Ryuichi Nishigaki, Hirotaka Yoshioka, Mitsuyoshi Nakao, Michio Oishi and Mitsuo Oshimura (2001) Large-scale evaluation of imprinting status in the Prader-Willi syndrome region: an imprinted direct repeat cluster resembling small nucleolar RNA genes. Human Molecular Genetics 10 (4): 383-394.

  20. Shin-ichi Horike, Kohzoh Mitsuya, Makiko Meguro, Noriko Kotobuki, Akiko Kashiwagi, Tomomi Notsu, Thomas C. Schulz, Yasuaki Shirayoshi and Mitsuo Oshimura (2000) Targeted disruption of the human LIT1 locus defines a putative imprinting control element playing an essential role for Beckwith-Wiedemann syndrome. Human Molecular Genetics 9 (14): 2075-2083.

  21. Shigeki Nishihara, Toshio Hayashida, Kohzoh Mitsuya, Thomas C. Schulz, Masahide Ikeguchi, Nobuaki Kaibara and Mitsuo Oshimura (2000) Multipoint imprinting analysis in sporadic colorectal cancers with and without microsatellite instability. International Journal of Oncology 17 (2): 317-322.

  22. Hiroyuki Kugoh, Kohzoh Mitsuya, Makiko Meguro, Katsuyo Shigenami, Thomas C. Schulz and Mitsuo Oshimura (1999) Mouse A9 cells containing single human chromosomes for analysis of genomic imprinting. DNA Research 6 (3): 165-172.

  23. Kohzoh Mitsuya, Makiko Meguro, Maxwell P. Lee, Motonobu Katoh, Thomas C. Schulz, Hiroyuki Kugoh, Mitsuaki A. Yoshida, Norio Niikawa, Andrew P. Feinberg and Mitsuo Oshimura (1999) LIT1, an imprinted antisense RNA in the human KvLQT1 locus identified by screening for differentially expressed transcripts using monochromosomal hybrids. Human Molecular Genetics 8 (7): 1209-1217.

  24. Maxwell P. Lee, Michael R. DeBaun, Kohzoh Mitsuya, Heidi L. Galonek, Sheri Brandenburg, Mitsuo Oshimura and Andrew P. Feinberg (1999) Loss of imprinting of a paternally expressed transcript, with antisense orientation to KVLQT1, occurs frequently in Beckwith-Wiedemann syndrome and is independent of insulin-like growth factor II imprinting. Proceedings of the National Academy of Sciences of the United States of America 96 (9): 5203-5208.

  25. Kohzoh Mitsuya, Makiko Meguro, Hajime Sui, Thomas C. Schulz, Hiroyuki Kugoh, Hiroshi Hamada and Mitsuo Oshimura (1998) Epigenetic reprogramming of the human H19 gene in mouse embryonic cells does not erase the primary parental imprint. Genes to Cells 3 (4): 245-255.

  26. Kohzoh Mitsuya, Hajime Sui, Makiko Meguro, Hiroyuki Kugoh, Yoshihiro Jinno, Norio Niikawa and Mitsuo Oshimura (1997) Paternal expression of WT1 in human fibroblasts and lymphocytes. Human Molecular Genetics 6 (13): 2243-2246.

  27. Makiko Meguro, Kohzoh Mitsuya, Hajime Sui, Katsuyo Shigenami, Hiroyuki Kugoh, Mitsuyoshi Nakao and Mitsuo Oshimura (1997) Evidence for uniparental, paternal expression of the human GABAA receptor subunit genes, using microcell-mediated chromosome transfer. Human Molecular Genetics 6 (12): 2127-2133.

  28. Kazunori Kitagawa, Xudong Wang, Izuho Hatada, Tetsuji Yamaoka, Hiroshi Nojima, Johji Inazawa, Tatsuo Abe, Kohzoh Mitsuya, Mitsuo Oshimura, Atsuo Murata, Morito Monden and Tsunehiro Mukai (1995) Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1. Genomics 30 (2): 257-263.

  29. Hiroshi Uejima, Kohzoh Mitsuya, Hiroyuki Kugoh, Izumi Horikawa and Mitsuo Oshimura (1995) Normal human chromosome 2 induces cellular senescence in the human cervical carcinoma cell line SiHa. Genes, Chromosomes & Cancer 14 (2): 120-127.

  30. Hiroyuki Kugoh, Yuzuki Nakagawa, Kohzoh Mitsuya, Tetsuo Mita, Mikio Suzuki, Noriyuki Suzuki, Hiroshi Uejima, Yoshihiro Yuasa and Mitsuo Oshimura (1995) Isolation and mapping of 186 new DNA markers on human chromosome 1. Genomics 27 (1): 207-210.